Fenbendazole is a broad-spectrum benzimidazole. It’s used to treat nematodal infections and gastrointestinal parasites in animals such as pinworms, hookworms, whipworms, Aelurostrongylus and Strongyloides tapeworms and stomach parasites (Giardia, Taenia and Strongyles). More recently it has been studied for cancer treatment due to its anti-cancer properties.
In this experiment, EMT6 tumor-bearing BALB/cRw mice were randomized at 100 mm3 of tumor volume to either serve as controls or be treated with three i.p. injections of fenbendazole per day (points represent geometric means+/-SEM; 7-8 mice/group). After the third dose, tumors were either irradiated or allowed to grow until they reached four-fold their original volume and then analyzed for tumor growth and radiation response (Table 1).
The results showed that fenbendazole significantly inhibited the growth of irradiated EMT6 tumors but not unirradiated ones. It also significantly inhibited the radiation response of these tumors, suggesting that fenbendazole enhances the effectiveness of conventional cancer treatments such as x-rays.
At regular doses, fenbendazole is considered safe with few adverse side effects. However, it’s important to tell your veterinarian if your pet has liver or kidney disease because this medication may cause a change in your pet’s liver enzymes that isn’t necessarily harmful, but could require smaller doses. It’s also essential to avoid mixing this medication with other drugs that could interact negatively with it. fenbendazole 222mg capsules for humans